Family Guy, its certainly funny, although sometimes I get annoyed by the length of some of the gag scenes, they just go on far too long.
Friends, I am sooooo sick of it.
Heroes, Love it to bits, but I've only seen 1 series, can't be considered greatest yet.
My Family, Mediocre comedy at best.
Prison Break, Not seen it. (yes I know!!)
Red Dwarf, Still remember watching the first ever episode when it was first shown, great show.
Sienfeld, Again, never seen it.
Top Gear, It's funny, but at the end of the day its blokes having a laugh with some cars and there really is no point in watching re-runs its only good the first time while the cars are new.
That leaves The Simpsons. Doesn't matter what mood I'm in, there's always time for an episode (or two). Can (and have) watched them over and over. So it gets my vote.