Harmison averages 40 against the aussies, and not with the bat. The aussies know what he's about, or rather what he isn't about, but Onions could surprise them - or Sidebottom. Our bowling attack is pretty much completely different, but here's a comparison of the possible line-ups
Flintoff 2009 vs Flintoff 2005 - I'd take the latter and his contribution from 2005
Swann vs Giles - I'd take Swann every time
Broad vs Hoggard - Hoggard picked up crucial wickets, Broad has more batting though
Onions/Panesar vs Harmison - I'd probably take either over wayward Harmison who has all the right attributes but that's about it
Anderson vs S.Jones - it will be hard for Anderson to emulate S.Jones, he averages 82.60 vs the aussies
I would suggest Anderson has replaced Hoggard. This to me is the most obvious comparison, as Anderson only became a consistent member of the Test side after Hoggard's last game. Both players exist to bowl full and swing the new ball. Both are suited to English conditions more than most others. Anderson has a worse history against Australia, but ought to be a bit more deadly than Hoggard at home, especially if he starting to find his career best form.
Broad offers similar qualities to Harmison, tall though maybe not quite as quick, but still quick enough; he often takes the new ball and can bowl threatening deliveries, but can also stray off his line and length. Broad is still very green, but the potential is there.
It leaves Onions as the replacement for Simon Jones, not really the best fit, but both are attacking bowlers who can surprise batsmen in the right conditions. It makes for a very abstract comparison, but if Onions has less "x-factor", he can certainly make up for it with load more fitness and consistency.